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Phospho-TrkB (Tyr516) Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540213

Catalog No. PA540213


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Description

Description

This antibody is predicted to react with human and mouse based on sequence homology.

TrkB is a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). TrkB is involved in the development and maintece of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
Specifications

Specifications

Phospho-TrkB (Tyr516)
Polyclonal
Unconjugated
NTRK2
Liquid
NTRK2
Synthesized peptide derived from human Trk B around the phosphorylation site of Y516.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Rat
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Q16620, Q63604
NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
25054, 4915
Documents
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