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Phospho-Tyrosine Hydroxylase (Ser62) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540238

Catalog No. PA540238


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Description

Description

This antibody is predicted to react with mouse, rat, and monkey based on sequence homology.

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson ft.s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
Specifications

Specifications

Phospho-Tyrosine Hydroxylase (Ser62)
Polyclonal
Unconjugated
TH
Liquid
TH
Synthesized peptide derived from human TH around the phosphorylation site of S62.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
P07101
TH; TYH; Tyrosine 3-monooxygenase; Tyrosine 3-hydroxylase; TH
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7054
Documents
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