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Phospho-YAP1 (Ser127) Rabbit anti-Human, Invitrogen™

Rabbit Recombinant Polyclonal Antibody

Manufacturer:  Invitrogen 711259

Catalog No. PI711259


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Description

Description

This antibody is predicted to react with Monkey, Bat, Pig and Mouse Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.
Specifications

Specifications

Phospho-YAP1 (Ser127)
Recombinant Polyclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P46937
Yes Associated Protein 1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage
Primary
10413
Immunocytochemistry, Immunofluorescence, Western Blot
11HCLC
Unconjugated
YAP1
Liquid
YAP1
Peptide corresponding to Human YAP1 (aa 124-132)
Protein A
RUO
Antibody
Oligoclonal
Human
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