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Tocris™ PHT 427

Dual Akt and PDK1 inhibitor; antitumor

Manufacturer:  Tocris™ 4598/50

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Catalog No. 45-985-0


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For Research Use Only


Specifications

Description

Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2µM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.
  • Chemical Name: 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
  • Formula: C20H31N3O2S2
  • CAS Number: 1191951-57-1
  • Solubility: Soluble to 100mM in DMSO
  • Purity: >98
Description & Specifications

Specifications

PHT 427
>98
50mg
PHT 427
409.61
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