Tocris™ PHT 427

Dual Akt and PDK1 inhibitor; antitumor

Manufacturer: Tocris™ 4598/50

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Catalog No. 45-985-0

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For Research Use Only


    Inhibitors PHT 427
    Purity >98
    Molecular Weight 409.61
    Quantity 50mg
    Product Type PHT 427

    Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2µM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

    • Chemical Name: 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
    • Formula: C20H31N3O2S2
    • CAS Number: 1191951-57-1
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >98

  • Description & Specifications

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