Tocris PHT 427
Dual Akt and PDK1 inhibitor; antitumor
Manufacturer: Tocris 4598/50
DescriptionDual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2µM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.
- Chemical Name: 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
- Formula: C20H31N3O2S2
- CAS Number: 1191951-57-1
- Solubility: Soluble to 100mM in DMSO
- Purity: >98
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