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Echelon Biosciences Research LabsSupplier Diversity Partner PI 3-Ka Inhibitor 2 1 mg  DFS Item

Manufacturer:  Echelon Biosciences Research LabsSupplier Diversity Partner B03041MG

3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol is a selective inhibitor for the α-isoform of PI 3-Kinase (IC50: PI 3-Kα = 2 nM, PI 3-Kβ = 16 nM, PI3-Kγ = 660 nM, PI3KC2β = 220 nM)). It showed >1000-fold selectivity vs. protein kinases such as PKA, KDR, PKCa, and E/CDK2 (IC50 = 91, 3.4, 466, 288 μM). It inhibited proliferation of A375 melanoma cells at 580 nM.

Catalog No. 50-720-018


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