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PIAS2 Mouse anti-Human, Clone: OTI5B4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526974

Catalog No. PIMA526974


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Description

Description

PIASX functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. PIASX binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
Specifications

Specifications

PIAS2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O75928
E3 SUMO-protein ligase PIAS2; Protein inhibitor of activated STAT2; Protein inhibitor of activated STAT x; Msx-interacting zinc finger protein; Miz1; DAB2-interacting protein; DIP; Androgen receptor-interacting protein 3; ARIP3; PIAS-NY protein; PIAS2; PIASX; PIASx-alpha; PIASx-beta
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
9063
Western Blot
OTI5B4
Unconjugated
PIAS2
Liquid
PIAS2
Full length human recombit protein of PIAS2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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