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Thermo Scientific™ Competition Rapid Equilibrium Dialysis (RED) Inserts

Evaluate competitive binding interactions by rapid equilibrium dialysis (RED) using this specially designed base plate and insert system.

$180.00 - $806.00


Products 2
Catalog Number Mfr. No. Description Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Description Quantity Price Quantity & Availability  
PI90087
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Thermo Scientific™
90087
Pierce Competition RED Device Inserts 10 inserts
Each for $180.00
Add to cart
 
PI90088
View Documents
Thermo Scientific™
90088
Pierce Competition RED Device Inserts 50 inserts
Each for $806.00
Add to cart
 
Description

Description

Thermo Scientific™ Pierce Competition RED Device Inserts and Base Plates comprise a specially designed system for evaluating competitive binding interactions using the technique called rapid equilibrium dialysis (RED).

The Competition RED Device was developed in association with pharmaceutical laboratories to more accurately model in vivo drug interactions by enabling equilibrium dialysis experiments to be performed in a multiplexed format involving competition for binding among different tissues. The system consists of disposable dialysis tube inserts and a reusable base plate made of high-grade PTFE. The Competition Base Plate is much like our regular RED Device Base Plate except that it is divided into different size chambers (wells) for positioning 2 to 8 RED Device Inserts per well. The format enables competitive dialysis experiments involving 2 to 15 separate tissue or protein fluid samples. Each Competition RED Insert contains either one or two separate dialysis chambers (each package includes a selection of both types). The Competition RED Device requires no extensive assembly or specialized equipment, and each chamber/well is easily accessible from the top of the device.

Highlights:

  • Easy to use – disposable tubes require no presoaking step, assembly, or specialized equipment

  • Short incubation time – design provides high surface-to-volume ratio of membrane to sample, enabling equilibrium to be reached within 2 to 4 hours

  • Flexible format – base plate contains several different chamber sizes, enabling small molecule partitioning studies involving 2 to 16 tissue or protein samples without waste

  • Robust – compartmentalized design eliminates potential for cross-talk or leakage

  • Reproducible and accurate – perform controlled experiments with multiple tissues to obtain screening results that have high predictability for in vivo studies with animal models

  • Validated quality – base plate is composed of chemically inert high-grade PTFE, eliminating non-specific binding and risk of contamination; each lot is functionally tested in a protein binding assay for guaranteed performance

Recommended for:

ADME-Tox studies for in vitro screening of drug partitioning between plasma and multiple tissues before in vivo experiments with animal models; Aids in determining formulation of drug dosage for in vivo studies; Drug-drug interaction studies; Competitive binding and dissociation constant determination for small molecules versus multiple targets

SDS

Patent pending

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