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Thermo Scientific™ Pierce™ High Capacity Endotoxin Removal Resin Available on GSA/VA Contract for Federal Government customers only.

Remove endotoxins (lipopolysaccharides or LPS) from samples before mass spectrometry using spin columns of poly(e-lysine) ligand on beaded cellulose.

Manufacturer:  Thermo Scientific™ 88271

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Catalog No. PI88271

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Reduce endotoxin levels in protein samples by greater than 99% in one hour while maximizing protein recovery with Thermo Scientific™ Pierce High Capacity Endotoxin Removal Resin.

The Pierce High Capacity Endotoxin Removal Resin combines porous cellulose beads and an FDA-approved food preservative, poly(epsilon-lysine), as an affinity ligand to selectively bind endotoxins. Endotoxin levels in protein samples are reduced by greater than 99% in as little as 1 hour using our spin cup format, and protein recovery is ≥85%. The modified polylysine affinity ligand eliminates the toxicity concerns associated with alternative technologies using polymixin B ligands and sodium deoxycholate buffers. Pierce High capacity Endotoxin Removal Resin is available as a slurry to pack a custom column that can be re-used at least 5 times with no loss in endotoxin removal efficiency. This resin is also available in a new single-use spin column format optimized for different sample volumes.


  • High capacity bind up to 2,000,000 EU/mL to eliminate at least 99% of endotoxins

  • Durable re-use resin up to 10 times with no loss in performance

  • Selective recover at least 85% of your protein sample

  • High performance compatible with FDA guidelines by reducing final EU concentration to less than 5 EU/mL

  • Fast our new spin cup format enables endotoxin depletion within 1 hour

  • Cleansingle-use spin columns avoid cross contamination of samples

  • Optimized spin cups are optimized for different sample volumes

  • Economical large-volume discounts available


Endotoxin-free water

Recommended for:

Eliminate endotoxins from protein or antibody samples prior to cell transfection or animal injection

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Proprietary Resin, Affinity
up to 2,000,000 EU/mL
Endotoxin Removal
Proprietary ligand on beaded cellulose slurried in 20% ethanol
Proprietary Ligand
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