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PIF1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 190061AP

Catalog No. 50-173-2319


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Description

Description

PIF1 is a single-stranded (ss) DNA-dependent ATPase as well as a DNA helicase that unwinds DNA in a 5 ft. to 3 ft. direction with respect to the DNA strand on which it binds first. This protein is critical to DNA replication and telomere length maintece in Saccharomyces cerevisiae. The PIF1 gene is highly conserved from yeast to humans. Mutations in the gene that encodes for PIF1 cause all telomeres to lengthen, suggesting that the PIF1 functions as a catalytic inhibitor of both new telomere formation and telomere elongation. Human PIF1 preferentially binds telomeric DNA where it inhibits telomerase activity. PIF1 specifically counteracts the RecQ homolog Sgs1 helicase activity, and degradation of PIF1 is mediated by the ubiquitin-26S proteasome pathway.
Specifications

Specifications

PIF1
0.33 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q1HG60, Q80SX8, Q9H611
C15orf20, PIF, PIF1
Rabbit
IgG
150 μL
-20°C
Primary
208084, 367645, 80119
Western Blot
Unconjugated
PIF1
Liquid
Pif1
PIF1 Fusion Protein Ag13522
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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