PIG3 Mouse anti-Human, Clone: OTI3B11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525712
DescriptionThe PIG (p53-induced gene) gene family encodes redox-controlling proteins that are involved in p53 tumor suppressor activity. One member of the PIG gene family, p53-inducible gene 3 (PIG3), is a p53 responsive gene that maps, in humans, to chromosome 2p and encodes a protein with significant homology to oxidoreductases. Oxidoreductases are enzymes involved in cellular responses to oxidative stress and irradiation, and they influence the involvement of PIG3 in the metabolism of reactive oxygen species. PIG3 is localized to the cytoplasm and induced in primary, non-transformed, and transformed cell cultures after exposure to genotoxic agents. The induction of PIG3 is p53 dependent and occurs with delayed kinetics as compared with other p53 downstream targets. PIG3 may act with caspase-8 as a key regulatory element in p53-dependent transcriptional deregulation by triggering the caspase cascade and mitochondrial breakdown. PIG3 is highly up-regulated by p53 and may be useful for detecting transient activation of p53.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PIG3, p53-induced gene 3 protein; quinone oxidoreductase PIG3; quinone oxidoreductase homolog; tumor protein p53-inducible protein 3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of TP53I3 produced in HEK293T cell|
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