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  8. Piperlongumine, Tocris Bioscience™

Piperlongumine, Tocris Bioscience™

Catalog Number 439650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
20069-09-4
C17H19NO5
317.34
MFCD00075706
VABYUUZNAVQNPG-BQYQJAHWSA-N
piperlongumine, piplartine, piplartin, unii-sgd66v4svj, sgd66v4svj, 5,6-dihydro-1-2e-1-oxo-3-3,4,5-trimethoxyphenyl-2-propen-1-yl-2 1h-pyridinone, e-1-3-3,4,5-trimethoxyphenyl acryloyl-5,6-dihydropyridin-2 1h-one, 1-e-3-3,4,5-trimethoxyphenyl prop-2-enoyl-2,3-dihydropyridin-6-one, e-5,6-dihydro-1-1-oxo-3-3,4,5-trimethoxyphenyl-2-propenyl-2 1h-pyridinone, 1-2e-3-3,4,5-trimethoxyphenyl prop-2-enoyl-1,2,5,6-tetrahydropyridin-2-one
637858
CHEBI:8241
1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-1,2,5,6-tetrahydropyridin-2-one
COC1=CC(\C=C\C(=O)N2CCC=CC2=O)=CC(OC)=C1OC
This item is not returnable. View return policy
20069-09-4
C17H19NO5
317.34
MFCD00075706
VABYUUZNAVQNPG-BQYQJAHWSA-N
piperlongumine, piplartine, piplartin, unii-sgd66v4svj, sgd66v4svj, 5,6-dihydro-1-2e-1-oxo-3-3,4,5-trimethoxyphenyl-2-propen-1-yl-2 1h-pyridinone, e-1-3-3,4,5-trimethoxyphenyl acryloyl-5,6-dihydropyridin-2 1h-one, 1-e-3-3,4,5-trimethoxyphenyl prop-2-enoyl-2,3-dihydropyridin-6-one, e-5,6-dihydro-1-1-oxo-3-3,4,5-trimethoxyphenyl-2-propenyl-2 1h-pyridinone, 1-2e-3-3,4,5-trimethoxyphenyl prop-2-enoyl-1,2,5,6-tetrahydropyridin-2-one
637858
CHEBI:8241
1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-1,2,5,6-tetrahydropyridin-2-one
COC1=CC(\C=C\C(=O)N2CCC=CC2=O)=CC(OC)=C1OC

Description

Induces apoptosis; increases p53 and ROS levels in cancer cells

Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
Quantity 50 mg
Formula Weight 317.34
Percent Purity >97%
Chemical Name or Material Piperlongumine

Safety and Handling

Recommended Storage Store at -20°C
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