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  8. PIT 1, Tocris Bioscience™

PIT 1, Tocris Bioscience™

Catalog Number 416850
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
53501-41-0
C14H10ClN3O4S
351.761
RIGXBXPAOGDDIG-UHFFFAOYSA-N
pit 1, pit-1, n-3-chloro-2-hydroxy-5-nitrophenyl carbamothioyl benzamide, n-3-chloro-2-hydroxy-5-nitrophenyl amino thioxomethyl benzamide, cbmicro_008144, 1-benzoyl-3-3-chloro-2-hydroxy-5-nitrophenyl thiourea, 3-benzoyl-1-3-chloro-2-hydroxy-5-nitrophenyl thiourea, pit 1/, n-3-chloro-2-hydroxy-5-nitro-phenyl carbamothioyl benzamide
3664359
N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC(=CC(=C2O)Cl)[N+](=O)[O-]
This item is not returnable. View return policy
53501-41-0
C14H10ClN3O4S
351.761
RIGXBXPAOGDDIG-UHFFFAOYSA-N
pit 1, pit-1, n-3-chloro-2-hydroxy-5-nitrophenyl carbamothioyl benzamide, n-3-chloro-2-hydroxy-5-nitrophenyl amino thioxomethyl benzamide, cbmicro_008144, 1-benzoyl-3-3-chloro-2-hydroxy-5-nitrophenyl thiourea, 3-benzoyl-1-3-chloro-2-hydroxy-5-nitrophenyl thiourea, pit 1/, n-3-chloro-2-hydroxy-5-nitro-phenyl carbamothioyl benzamide
3664359
N-[(3-chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC(=CC(=C2O)Cl)[N+](=O)[O-]

Description

PIP3 antagonist. Blocks PIP3-PH interaction; inhibits Akt signaling

Selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.
Quantity 50 mg
Formula Weight 351.76
Percent Purity >99%
Chemical Name or Material PIT 1

Safety and Handling

Recommended Storage Store at +4°C
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