Invitrogen™ PIT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110201

Catalog No. PIPA5110201

Description

Immunogen sequence: MDSPEIRELE KFANEFKVRR IKLGYTQTNV GEALAAVHGS EFSQTTICRF ENLQLSFKNA CKLKAILSKW LEEAEQVGAL YNEKVGANER KRKRRTTISI AAKDALERHF GEQNKPSSQE IMRMAEELNL EKEVVRVWFC NRRQREKRVK.

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.

Specifications

• Antigen: PIT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: POU1F1
• Gene Alias: CPHD1; dw; dwarf; GHF1; GHF-1; GHF1A; growth hormone factor 1; Hmp1; homeodomain protein for Growth Hormone (GH); PIT1; pit-1; Pit1-rs1; PIT1Z; Pituary specific transcription factor 1 (growth hormone factor 1); pituitary specific transcription factor 1; pituitary specific transcription factor 1, related sequence 1; pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU class 1 homeobox 1; POU domain, class 1, transcription factor 1; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1); POU1F1; POU1F1a; transcription factor Pit-1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5449
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.87 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P28069
• Gene Symbols: POU1F1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 124-273 of human POU1F1 (NP_0002971?).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov