PITPNB Mouse anti-Human, Clone: OTI6H10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527120
DescriptionThe lipid binding proteins known as phosphatidylinositol transfer proteins (PITP) facilitate the formation of phosphatidylinositol derived second messenger molecules, which are related to the phospholipase C and phosphoinositide 3-kinase pathways. PITP are ubiquitously expressed proteins that transfer phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes enriched in PI or PC to membranes that are deficient in PI or PC. PITP mobilizes PI from the endoplasmic recticulum and regulates the release of PI from stored vesicles in the Golgi network. In mammalian cells, three smaller forms of soluble PITP are present, designated PITP alpha, PITP beta and retinal degeneration B (rdgB) beta. PITP beta is a 271 amino acid protein that is widely expressed in various tissues. Though required for Golgi targeting, constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity. There are two isoforms of PITP beta that are produced as a result of alternative splicing events.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PI-TP-beta, PtdInsTP, VIB1B, PtdIns transfer protein beta, phosphatidylinositol transfer protein beta isoform, phosphotidylinositol transfer protein, beta, ptdInsTP beta|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of PITPNB produced in E.coli|
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