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PKN3 Mouse anti-Human, Clone: OTI11D8, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527294

Catalog No. PIMA527294


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Description

Description

PKN3, a protein kinase C-related molecule, mediates maligt cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
Specifications

Specifications

PKN3
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q6P5Z2
Serine/threonine-protein kinase N3; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; PKNBETA; PKN3
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29941
Western Blot
OTI11D8
Unconjugated
PKN3
Liquid
PKN3
Human recombit protein fragment corresponding to amino acids 1-275 of PKN3 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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