PKN3 Mouse anti-Human, Clone: OTI11D8, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527294
DescriptionPKN3, a protein kinase C-related molecule, mediates maligt cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|Serine/threonine-protein kinase N3; Protein kinase PKN-beta; Protein-kinase C-related kinase 3; PKNBETA; PKN3|
|-20° C, Avoid Freeze/Thaw Cycles|
|Human recombit protein fragment corresponding to amino acids 1-275 of PKN3 produced in E.coli|
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