Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Pleckstrin Mouse anti-Human, Clone: OTI4G6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525038

Catalog No. PIMA525038


Add to cart

Description

Description

Activation of protein kinase C (PKC) in platelets results in immediate phosphorylation of pleckstrin (previously called 40K or P47), the major PKC substrate in platelets. Pleckstrin contains a Ca2+-binding  ft.EF-hand ft. structure and PKC phosphorylation sites at Ser-113 and Ser-117. The N and C termini of pleckstrin contain two pleckstrin homology domains (PH), which mediate protein-protein and protein-lipid interactions. Pleckstrin is highly expressed in human neutrophils. Pleckstrin is rapidly phosphorylated following treatment of neutrophils in response to inflammatory stimuli, probably by nonconventional PKC isoforms delta or zeta, which are expressed in human neutrophils. Phosphorylation by nonconventional PKC isoforms induces a conformational change in pleckstrin that promotes its interaction with membranes and/or with the cytoskeleton, serving to target proteins or lipids recognized by PH domains to sites where they can contribute to the microbicidal response.
Specifications

Specifications

Pleckstrin
Monoclonal
0.78 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P08567
Pleckstrin; Platelet 47 kDa protein; p47;PLEK; P47
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5341
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
OTI4G6
Unconjugated
PLEK
Liquid
PLEK
Full length human recombit protein of PLEK produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit