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PLEKHM1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 162021AP

Catalog No. 50-173-0786


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Description

Description

PLEKHM1 is a member of the M family of Pleckstrin homolog domain-containing proteins, a group of proteins containing a RUN domain, two pleckstrin homology domains, and a cysteine-rich domain. It was identified through segregation analysis as a cause of osteopetrosis in humans. PLEKHM1 co-localizes with Rab7 to late endosomal/lysosomal vesicles in HEK293 and osteoclast-like cells, with this co-localization dependent on the prenylation of Rab7. Monocytes from a patient homozygous for a mutated form of PLEKHM1differentiated into osteoclasts normally, but failed to form ruffled borders and showed little evidence of bone resorption when cultured on dentine discs. Another mutation of PLEKHM1 impaired vesicular acidification and increased TRACP secretion in osteoclasts, suggesting that PLEKHM1 has critical roles in endosomal maturation and may be important in osteoclast-osteoblast cross-talk.
Specifications

Specifications

PLEKHM1
0.2 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q5PQS0, Q7TSI1, Q9Y4G2
162 kDa adapter protein, AP162, B2, KIAA0356, OPTB6, PLEKHM1
Rabbit
IgG
150 μL
-20°C
Primary
303584, 353047, 9842
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PLEKHM1
Liquid
Plekhm1
PLEKHM1 Fusion Protein Ag9145
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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