Invitrogen™ PLEKHO1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520827

Catalog No. PIPA520827

Description

A suggested positive control is human lung tissue lysate. PA5-20827 can be used with blocking peptide PEP-0941.

CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

Specifications

• Antigen: PLEKHO1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLEKHO1
• Gene Alias: 2810052M02Rik; Casein kinase 2-interacting protein 1; C-Jun-binding protein; CK2 interacting protein 1; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; CKIP1; CKIP-1; HQ0024c; HQ0024c protein; JBP; Jun zipper-associated 2; Jza2; JZA-20; OC120; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1; pleckstrin homology domain containing O1; pleckstrin homology domain containing, family O member 1; pleckstrin homology domain-containing family O member 1; pleckstrin homology domain-containing family O member 1-like; PLEKHO1; RGD1311487; RP11-458I7.3; TNF intracellular domain-interacting protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 310674, 51177, 67220
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q53GL0, Q5BJM5, Q9JIY0
• Gene Symbols: PLEKHO1
• Immunogen: An 18 amino acid peptide from near the carboxy terminus of human CKIP1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov