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PLK1 Rabbit anti-Human, Unconjugated, Clone: ARC1570, Invitrogen™

Rabbit Monoclonal Antibody

Manufacturer:  Invitrogen MA535868

Catalog No. PIMA535868


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Description

Description

PLK1 is a Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
Specifications

Specifications

PLK1
ARC1570
PBS with 50% glycerol and 0.2% sodium azide; pH 7.3
P53350
BOS_22765; Plk; Plk1; PLK-1; plx1; polo like kinase; polo-like kinase; Polo-like kinase 1; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13; STPK14; XELAEV_18047692mg
Rabbit
IgG
100 μL
-20°C, Avoid Freeze/Thaw Cycles
Primary
5347
Western Blot
Unconjugated
Plk1
Liquid
Plk1
A phospho specific peptide corresponding to residues surrounding T210 of human PLK1
Protein A
RUO
Antibody
Monoclonal
Human
SDS
Documents
Product Certifications
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