PLOD2 Mouse anti-Human, Clone: OTI6D1, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526585
DescriptionThe protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|LH2, PLOD2, TLH, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2, 2-oxoglutarate 5-dioxygenase 2, procollagen-lysine, telopeptide lysyl hydroxylase|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Human recombit protein fragment corresponding to amino acids 359-640 of PLOD2 produced in E.coli|
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