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PLOD2 Mouse anti-Human, Clone: OTI6D1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526585

Catalog No. PIMA526585


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Description

Description

The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications

Specifications

PLOD2
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
O00469
LH2, PLOD2, TLH, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2, 2-oxoglutarate 5-dioxygenase 2, procollagen-lysine, telopeptide lysyl hydroxylase
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5352
Immunohistochemistry (Paraffin), Western Blot
OTI6D1
Unconjugated
PLOD2
Liquid
PLOD2
Human recombit protein fragment corresponding to amino acids 359-640 of PLOD2 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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