Invitrogen™ PLS3 Monoclonal Antibody (GT236)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA527771

Catalog No. PIMA527771

Description

Positive Control: 293T, A431, HeLa, HepG2 Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (89%), Xenopus laevis (91%), Chicken (95%), Rhesus Monkey (100%), Bovine (99%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Phospholipid scramblases (PLS) translocate phospholipids bidirectionally between inner and outer leaflets of the plasma membrane and are implicated in apoptosis (1,2). Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.

Specifications

• Antigen: PLS3
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P13797, Q99K51
• Gene Symbols: PLS3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human T-Plastin. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: GT236
• Conjugate: Unconjugated
• Gene: PLS3
• Gene Alias: AI115446; AL024105; BMND18; LOW QUALITY PROTEIN: plastin-3; MGC128570 protein; plastin 3; plastin 3 (T isoform); plastin 3 (T-isoform); plastin 3, T; plastin-3; PLS3; T fimbrin; T plastin; T-fimbrin; T-plastin
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 102866, 5358
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid