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Plumbagin, Tocris Bioscience™

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Quantity:
50mg
This item is not returnable. View return policy
481-42-5
C11H8O3
188.182
VCMMXZQDRFWYSE-UHFFFAOYSA-N
plumbagin,plumbagine,5-hydroxy-2-methyl-1,4-naphthoquinone,plumbaein,plumbagone,2-methyljuglone,5-hydroxy-2-methyl-1,4-naphthalenedione,2-methyl-5-hydroxy-1,4-naphthoquinone,5-hydroxy-2-methyl-1,4 naphthoquinone,1,4-naphthalenedione, 5-hydroxy-2-methyl
10205
CHEBI:8273
5-hydroxy-2-methylnaphthalene-1,4-dione
CC1=CC(=O)C2=C(C1=O)C=CC=C2O
This item is not returnable. View return policy
481-42-5
C11H8O3
188.182
VCMMXZQDRFWYSE-UHFFFAOYSA-N
plumbagin,plumbagine,5-hydroxy-2-methyl-1,4-naphthoquinone,plumbaein,plumbagone,2-methyljuglone,5-hydroxy-2-methyl-1,4-naphthalenedione,2-methyl-5-hydroxy-1,4-naphthoquinone,5-hydroxy-2-methyl-1,4 naphthoquinone,1,4-naphthalenedione, 5-hydroxy-2-methyl
10205
CHEBI:8273
5-hydroxy-2-methylnaphthalene-1,4-dione
CC1=CC(=O)C2=C(C1=O)C=CC=C2O

Description

Induces G2/M cell cycle arrest; anticancer

Anticancer agent. Induces G2/M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation; inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. Promotes autophagic cell death in MDA-MB-231 and MCF-7 cells and inhibits Akt/mTOR signaling. Induces intracellular ROS generation in a PI 5-kinase-dependent manner. Also inhibits p300-mediated acetylation of p53.
Quantity 50mg
Formula Weight 188.18
Percent Purity >98%
Chemical Name or Material Plumbagin

Safety and Handling

Recommended Storage : Store at -20°C