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PMCA2 Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 196781AP

Catalog No. 50-173-2482


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Description

Description

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
Specifications

Specifications

PMCA2
0.19 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q01814
ATP2B2, PMCA2, PMCA2a, PMCA2i
Rabbit
IgG
150 μL
-20°C
Primary
491
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
ATP2B2
Liquid
ATP2B2
Peptide
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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