PNPase Mouse anti-Human, Clone: 4C11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527859
Positive Control: Jurkat, Raji, K562, THP-1 Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.PNPT1 (polyribonucleotide nucleotidyltransferase 1, mitochondirla) is a RNA-binding protein implicated in numerous RNA metabolic processes. It catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3 ft.-to-5 ft. direction. PNPT1 is a component of the mitochondrial degradosome (mtEXO) complex that degrades 3 ft. overhang double-stranded RNA with a 3 ft.-to-5 ft. directionality in an ATP-dependent manner. It is required for correct processing and polyadenylation of mitochondrial mRNAs. It plays a role as a cytoplasmic RNA import factor, in mitochondrial morphogenesis and respiration, regulation of expression of the electron transport chain, regulation of the stability of specific mature miRNAs in melanoma cells, and RNA cell surveilance. Mutations of the gene can result in combined oxidative phosphorylation deficiency 13 (COXPD13) and deafness, autosomal recessive, 70 (DFNB70).
|PBS with no preservative|
|DKFZp762K1914, old-35, OLD35, PNPASE, PNPT1, old 35|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunoprecipitation, Western Blot|
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