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POLR3B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 165741AP

Catalog No. 50-173-1032


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Description

Description

Members of the Protein kinase C (PKC) family of serine/threonine protein kinases are grouped by their activation mechanism. Classical or conventional PKCs (PKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol. The Ca2+ insensitive novel PKCs (PKCs epsilon-, delta-, theta- and eta) are also activated by diacylglycerol and phosphatidylserine. The atypical PKCs (PKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbolesters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. PKCs are involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP.
Specifications

Specifications

POLR3B
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P59470, Q9NW08
C128, POLR3B, RNA polymerase III subunit C2, RPC2
Rabbit
IgG
150 μL
-20°C
Primary
362858, 55703, 70428
Western Blot
Unconjugated
POLR3B
Liquid
Polr3b
POLR3B Fusion Protein Ag9856
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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