Invitrogen™ POLR3D Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564342

Catalog No. PIPA564342

Description

Immunogen sequence: LPKDVSVAEL LRELSLTKEE ELLFLQLPDT LPGQPPTQDI KPIKTEVQGE DGQVVLIKQE Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 95%.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Specifications

• Antigen: POLR3D
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Polr3d
• Gene Alias: 2810426M17Rik; 44kDa; AI326118; AW489084; BN51; BN51 (BHK21) temperature sensitivity complementing; Bn51t; DNA-directed RNA polymerase III 47 kDa polypeptide; DNA-directed RNA polymerase III subunit C4; DNA-directed RNA polymerase III subunit D; DNA-directed RNA polymerase III subunit RPC4; HOX1C; Polr3d; polymerase (RNA) III (DNA directed) polypeptide D; polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; polymerase (RNA) III subunit D; Protein BN51; RNA polymerase III 47 kDa subunit; RNA polymerase III subunit C4; RNA polymerase III subunit D; RPC4; RPC53; RPC53 homolog; temperature sensitive complementation, cell cycle specific, tsBN51; TSBN51
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 661
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P05423
• Gene Symbols: Polr3d
• Immunogen: Recombinant protein corresponding to Human POLR3D. Recombinant protein control fragment (Product #RP-104050).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG