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Cell Signaling TechnologySupplier Diversity Partner Phospho-Stat6 (Tyr641) Antibody 100 ul DFS Item

Manufacturer:  Cell Signaling TechnologySupplier Diversity Partner 9361S

9361S , Upon activation by Janus kinases, Stat6 translocates to the nucleus where it regulates cytokine-induced gene expression. Stat6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13 (1-4). In addition, Stat6 is activated by IFN-α in B cells, where it forms transcriptionally active complexes with Stat2 and p48 (5,6). Protein phosphatase 2A is also involved in regulation of IL-4-mediated Stat6 signaling (7).

Catalog No. 50-194-813


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