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PPAR delta Mouse anti-Human, Clone: OTI4D10, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527427

Catalog No. PIMA527427


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Description

Description

This gene encodes a member of the peroxisome proliferator-activated receptor family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli , a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
Specifications

Specifications

PPAR delta
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q03181
FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB, PPAR-beta, PPAR-delta, nuclear hormone receptor 1, nuclear receptor subfamily 1 group C member 2, peroxisome proliferator-activated nuclear receptor beta/delta variant 2, peroxisome proliferator-activated receptor beta
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5467
Immunohistochemistry (Paraffin), Western Blot
OTI4D10
Unconjugated
PPARD
Liquid
PPARD
Human recombit protein fragment corresponding to amino acids 1-244 of PPARD produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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