PPARA Mouse anti-Human, Clone: OTI1E11, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA503541

Catalog No. 50-167-4405

Description

Peroxisome proliferator-activated receptor alpha (PPARA) is a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulatetranscrption of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.

Specifications

• Antigen: PPARA
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q07869
• Gene Alias: NR1C1, PPAR, PPARalpha, hPPAR
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 5465

• Applications: Immunocytochemistry, Immunofluorescence, Western Blot
• Clone: OTI1E11
• Conjugate: Unconjugated
• Gene: PPARA
• Format: Liquid
• Gene Symbols: PPARA
• Immunogen: Human recombit protein fragment corresponding to amino acids 145-420 of human PPARA produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human