PPARA Mouse anti-Human, Mouse, Clone: OTI1E8, liquid, TrueMAB
Mouse Monoclonal Antibody
Manufacturer: OriGene TA503540
DescriptionPeroxisome proliferator-activated receptor alpha (PPARA) is a member of the nuclear hormone receptor subfamily. Upon activation, PPARA forms heterodimers with retinoid X receptors (RXRs), and functions to regulatetranscrption of specific gene sequences. In particular, PPARA controls genes involved in the peroxisomal and mitochondrial beta oxidation pathways, fatty acid uptake, and triglyceride catabolism in the liver and skeletal muscle. PPARA also has anti-inflammatory and anti-proliferative effects and prevents the proatherogenic effects of cholesterol accumulation in macrophages by stimulating cholesterol efflux. PPARA is the main target of fibrate drugs; hypolipidemic agents used in the treatment of dyslipidemia and the prevention of cardiovascular disease. They could also be used for the treatment of type II diabetes.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide|
|NR1C1, PPAR, PPARalpha, hPPAR|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|Human recombit protein fragment corresponding to amino acids 145-420 of human PPARA produced in E.coli.|
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