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PPP2R3B Rabbit anti-Human, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 245021AP

Catalog No. 50-173-4393


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Description

Description

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombit MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.
Specifications

Specifications

PPP2R3B
0.55 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9Y5P8
NY REN 8, PP2A subunit B isoform PR48, PPP2R3B, PPP2R3L, PPP2R3LY, PR48
Rabbit
IgG
150 μL
-20°C
Primary
28227
Western Blot
Unconjugated
PPP2R3B
Liquid
PPP2R3B
PPP2R3B Fusion Protein Ag21366
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Documents
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