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PPP4C Mouse anti-Human, Clone: OTI2E4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527269

Catalog No. PIMA527269


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Description

Description

Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
Specifications

Specifications

PPP4C
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P60510
PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 (formerly X), catalytic subunit, protein phosphatase X, catalytic subunit, serine/threonine-protein phosphatase 4 catalytic subunit
Mouse
IgG2a
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5531
Immunohistochemistry (Paraffin), Western Blot
OTI2E4
Unconjugated
PPP4C
Liquid
PPP4C
Full length human recombit protein of PPP4C produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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