PPP4C Mouse anti-Human, Clone: OTI2H7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527270
DescriptionProtein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 (formerly X), catalytic subunit, protein phosphatase X, catalytic subunit, serine/threonine-protein phosphatase 4 catalytic subunit|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of PPP4C produced in E.coli|
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