Potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90nM). Reduces the size and number of renal cysts in an embryonic kidney culture model of polycystic kidney disease. Also increases VEGF-A production from airway epithelial cells in vitro.
Chemical Name: 6,7-Dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
CAS Number: 931706-15-9
Solubility: Soluble to 20mM in DMSO with gentle warming
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