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Tocris Bioscience™ PQ 69 Available on GSA/VA Contract for Federal Government customers only.

Potent and selective A1 antagonist/inverse agonist

$248.50 - $1046.00


Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
535110 Available on GSA/VA Contract for Federal Government customers only. View Documents Tocris Bioscience™
5351/10
Each for $248.50
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535150 View Documents Tocris Bioscience™
5351/50
Each for $1,046.00
Add to cart
 
Description

Description

Potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA -induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.

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