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PQBP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 162641AP

Catalog No. 50-173-0838



Description

Description

Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit. Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA granules. Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol. Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production.
Specifications

Specifications

PQBP1
0.22 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O60828, Q6PCT5, Q91VJ5
MRX55, MRXS3, MRXS8, PQBP 1, PQBP1, RENS1, SHS
Rabbit
IgG
150 μL
-20°C
Primary
10084, 302557, 54633
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
PQBP1
Liquid
Pqbp1
PQBP1 Fusion Protein Ag9329
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Documents
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