Invitrogen™ PREP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556724

Catalog No. PIPA556724

Description

Immunogen sequence: LVKYSPLHNV KLPEADDIQY PSMLLLTADH DDRVVPLHSL KFIATLQYIV GRSRKQSNPL LIHVDTKAGH GAGKPTAKVI EEVSDMFAFI ARCLNVDWIP Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

p33cdk2 associates with cyclin A in human cells. Kinase activity associated with cyclin A-cdc2 is found only in G2-phase. Cdk2 also complexes with cyclins E, D1, and D3. Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.

Specifications

• Antigen: PREP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PREP
• Gene Alias: AI047692; AI450383; D10Wsu136e; dJ355L5.1 (prolyl endopeptidase); EC 3.4.21.26; MGC16060; PE; PE {ECO:0000250; PEP; Pop; post-proline cleaving enzyme; post-proline cleaving enzyme {ECO:0000250; Prep; prep {ECO:0000312; Prolyl endopeptidase; prolyl endopeptidase {ECO:0000250; prolyl oligopeptidase; RGD:620841}; rPop; UniProtKB:P23687}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5550
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P48147
• Gene Symbols: PREP
• Immunogen: Recombinant protein corresponding to Human PREP. Recombinant protein control fragment (Product #RP-94644).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG