Presenilin-1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 161631AP
This antibody is specific to isoform 1 (53 kDa), isoform 2 (52 kDa), isoform 4 (21 kDa), isoform 7 (49 kDa) of this protein.Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer ft.s disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer ft.s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer ft.s disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P49768, P49769, P97887|
|AD3, FAD, Presenilin-1, Protein S182, PS 1, PS1, PS1 CTF12, PSEN1, PSNL1, S182|
|19164, 29192, 5663|
|Immunoprecipitation, Western Blot|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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