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PRKAR1A Mouse anti-Human, Clone: OTI6C7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524981

Catalog No. PIMA524981


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Description

Description

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
Specifications

Specifications

PRKAR1A
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P10644
AMP-dependent protein kinase type I-alpha regulatory subunit,Tissue-specific extinguisher 1,TSE1,PKR1, PRKAR1, TSE1,PRKAR1A
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5573
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
OTI6C7
Unconjugated
PRKAR1A
Liquid
PRKAR1A
Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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