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PRKAR1B Mouse anti-Human, Clone: OTI1B4, liquid, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner TA502794

Catalog No. 50-167-3806


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Description

Description

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified that each represent specific gene products. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcrip- tion factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.
Specifications

Specifications

PRKAR1B
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
P31321
PRKAR1
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
5575
Immunocytochemistry, Immunofluorescence, Western Blot
OTI1B4
Unconjugated
PRKAR1B
Liquid
PRKAR1B
Full length human recombit protein of human PRKAR1B produced in HEK293T cell.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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