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PRKAR1B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 179911AP

Catalog No. 50-173-1922


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Description

Description

The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified that each represent specific gene products. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcrip- tion factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.
Specifications

Specifications

PRKAR1B
0.35 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P12849, P31321, P81377
PRKAR1, PRKAR1B
Rabbit
IgG
150 μL
-20°C
Primary
19085, 25521, 5575
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PRKAR1B
Liquid
Prkar1b
PRKAR1B Fusion Protein Ag12426
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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