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PRKG2 Mouse anti-Human, Clone: OTI10D5, lyophilized, TrueMAB™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  OriGeneSupplier Diversity Partner CF807705

Catalog No. 50-166-8429


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler ft.s diarrhea and about 50% of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
Specifications

Specifications

PRKG2
Monoclonal
Unconjugated
PRKG2
Lyophilized
PRKG2
Human recombit protein fragment corresponding to amino acids 40-320 of human PRKG2 (NP_006250 produced in E.coli.
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Western Blot
OTI10D5
PBS with 8% trehalose and no preservative; pH 7.3
Q13237
PRKGR2, cGK2, cGKII
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
5593
SDS
Documents
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