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Progerin Mouse anti-Human, Clone: 13A4, Active Motif™

Mouse Monoclonal Antibody

Manufacturer:  Active MotifSupplier Diversity Partner 39966

Encompass

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Catalog No. 50-199-3008


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Description

Description

Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin-A/C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acid internal deletion within the C-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of the LMNA gene.
Specifications

Specifications

Progerin
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
P02545
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32
This Progerin antibody was raised against a peptide corresponding to amino acids 604-611 of human Progerin.
Protein G
RUO
Antibody
Monoclonal
Human
LMNA
13A4
Unconjugated
LMNA
Liquid
Mouse
IgG1, kappa
10 μg
-20°C, Avoid Freeze/Thaw Cycles
Primary
4000
SDS
Documents
Product Certifications
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