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Protein C Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA586875
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DescriptionProtein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 μg/ml. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulmis, and recurrent venous thrombosis.
|Vitamin K-dependent protein C (EC:220.127.116.11); Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; PROC|
|19123, 25268, 5624|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P04070, P31394, P33587|
|A synthetic peptide corresponding to residues in Human PROC.|
|Human, Mouse, Rat|
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