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Protocadherin Gamma A Mouse anti-Human, Mouse, Clone: S144-32, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA527649

Catalog No. PIMA527649


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Description

Description

The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Specifications

Specifications

Protocadherin Gamma A
Monoclonal
1 mg/ml
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Q91Y11, Q9Y5H5
PCDH gamma A, PCDH-gamma-A, PCDHGA, Protocadherin gamma A, Protocadherin gamma subfamily A, Gamma Protocadherin A (pan), Pan-Gamma-Protocadherin-A, Pan Gamma Protocadherin A
Mouse
IgG2b
100 μg
-20°C
Primary
192161, 9752
Immunocytochemistry, Immunofluorescence, Western Blot
S144-32
Unconjugated
PCDHA9
Liquid
PCDHA9
Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3. Human: 80% identity (68/84 amino acids identical) >75% identity with other Gamma-protocadherin-A proteins
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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