Invitrogen™ PRPF18 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558031

Catalog No. PIPA558031

Description

Immunogen sequence: SNPVLELELA EEKLPMTLSR QEVIRRLRER GEPIRLFGET DYDAFQRLRK IEILTPEVNK GLRNDLKAAL DKIDQQYLNE IVG Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 99%.

PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein that localizes to nuclear speckles and plays a role in the second step of pre-mRNA splicing. A member of the PRP18 family, PRPF18 contains seven WD repeats and exists as two alternatively spliced isoforms which are encoded by a gene located on human chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. Other chromosome 10 associated disorders include Cockayne syndrome, tetrahydrobiopterin deficiency and trisomy 10.

Specifications

• Antigen: PRPF18
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRPF18
• Gene Alias: 2810441A10Rik; HPRP18; HPRP18 homolog; Kcrf; Potassium channel regulatory factor; Pprf18; pre-mRNA processing factor 18; pre-mRNA-splicing factor 18; Prp18; PRP18 homolog; PRP18 pre-mRNA processing factor 18 homolog; PRP18 pre-mRNA processing factor 18 homolog (yeast); PRP18 pre-mRNA processing factor 18 homolog(PRPF18); Prpf18
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171552, 67229, 8559
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8BM39, Q99633, Q9JKB8
• Gene Symbols: PRPF18
• Immunogen: Recombinant protein corresponding to Human PRPF18. Recombinant protein control fragment (Product #RP-97130).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov