PRRX1 Mouse anti-Human, Clone: OTI1E10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526580
DescriptionThe homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|PRRX1; paired related homeobox 1; PHOX1; PMX1; PRX1; homeobox protein PHOX1; paired mesoderm homeo box 1; paired mesoderm homeobox 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of PRRX1 produced in E.coli|
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