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PRTFDC1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA551329

Catalog No. PA551329


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Description

Description

The antibody detects endogenous levels of total PRTFDC1 protein.

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
Specifications

Specifications

PRTFDC1
Polyclonal
Unconjugated
PRTFDC1
Liquid
PRTFDC1
Full length fusion protein of human PRTFDC1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
0.7 mg/mL
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Q9NRG1
HHGP
Rabbit
IgG
100 μL
-20°C
Primary
56952
Documents
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