PSMB7 Mouse anti-Human, Mouse, Clone: OTI1B2, liquid, TrueMAB™ 

Mouse Monoclonal Antibody

Manufacturer:  OriGene TA504456

Catalog No. 50-167-5145

Description

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

Specifications

• Antigen: PSMB7
• Classification: Monoclonal
• Concentration: 0.99 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P70195, Q99436
• Gene Alias: Z
• Host Species: Mouse
• Isotype: IgG1
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 19177, 5695

• Applications: Western Blot
• Clone: OTI1B2
• Conjugate: Unconjugated
• Gene: PSMB7
• Format: Liquid
• Gene Symbols: Psmb7
• Immunogen: Human recombit protein fragment corresponding to amino acids 58-277 of human PSMB7 produced in E.coli.
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Monoclonal
• Target Species: Human, Mouse