PSMC3 Mouse anti-Canine, Human, Clone: OTI9F3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525046
DescriptionProteolytic degradation is critical to the maintece of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman ft.s syndrome, and Liddle syndrome.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|TBP1, 26S protease regulatory subunit 6A, 26S proteasome AAA-ATPase subunit RPT5, TBP-1, Tat-binding protein 1, human immunodeficiency virus tat transactivator binding protein-1, proteasome 26S subunit ATPase 3, proteasome subunit P50|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of PSMC3 produced in HEK293T cell|
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